AP Biology Unit 4: Cell Communication and Cell Cycle

Unit 4 covers cell communication and the cell cycle: signal transduction pathways, feedback, mitosis and its checkpoints. Signalling questions are almost always about what happens when one step of a pathway fails.

162 questions7 CED topics49% with a figure
How this unit behaves

What 162 questions on it look like

49% of the questions come with a figure — a graph, diagram or data display. Reading the figure correctly is most of the work before any content knowledge applies.

Introduction to Signal Transduction55
Cell Communication45
Cell Cycle25
Regulation of Cell Cycle17
Feedback9
Signal Transduction8
Changes in Signal Transduction Pathways3

Questions per CED topic.

From the bank

Three real cell communication and cell cycle questions

Drawn from the practice pool, not from the mock papers.

Feedback · Concept Explanation

During childbirth, pressure on the cervix stimulates release of oxytocin. Oxytocin increases uterine contractions, which increases pressure on the cervix. Which type of feedback is illustrated?

  1. AHydrolysis because water breaks a polymer bond
  2. BThe loop reinforces the original signalcorrect
  3. CNegative feedback because the response cancels the stimulus
  4. DAllele frequencies change randomly
Why B is correct

Positive feedback amplifies the original stimulus. Oxytocin increases contractions, which increases cervical pressure and further oxytocin release.

The stem asks students to explain a specific mechanism, not just recall a unit term: "During childbirth, pressure on the cervix stimulates release of oxytocin. Oxytocin increases uterine contractions,...". The correct choice is supported by Oxytocin increases contractions, which increases cervical pressure and further oxytocin release. The tempting alternatives such as Hydrolysis because water breaks a polymer bond or Negative feedback because the response cancels the stimulus fail because they do not produce the same outcome described in the stem.

Common mistakes. Do not stop at a nearby term such as Hydrolysis because water breaks a polymer bond or Negative feedback because the response cancels the stimulus. The explanation has to make "Positive feedback because the response amplifies the stimulus" fit this stem clue: "During childbirth, pressure on the cervix stimulates release of oxytocin. Oxytocin...".

Regulation of Cell Cycle · Representing and Describing Data · with figure

Cells are exposed to DNA-damaging radiation. Which conclusion is best supported by the data? Use Figure 1 to answer the question.

  1. AThe checkpoint protein eliminates all cell division in healthy cells.
  2. BThe checkpoint protein is required for photosynthesis.
  3. CThe checkpoint protein increases DNA damage before mitosis.
  4. DThe checkpoint protein helps prevent damaged cells from entering mitosis.correct
Why D is correct

Cells lacking the checkpoint protein enter mitosis much more often after damage, supporting that the normal checkpoint helps block mitosis when DNA is damaged.

The evidence in the prompt matters before the topic label: "Cells are exposed to DNA-damaging radiation. Which conclusion is best supported by the data". The supported answer is "checkpoint protein helps prevent damaged cells from entering mitosis" because Cells lacking the checkpoint protein enter mitosis much more often after damage, supporting that the normal checkpoint helps block mitosis when DNA is damaged. Distractors such as checkpoint protein eliminates all cell division in healthy cells or checkpoint protein is required for photosynthesis either ignore the stated pattern or name a related concept without matching the evidence.

Common mistakes. Do not stop at a nearby term such as checkpoint protein eliminates all cell division in healthy cells or checkpoint protein is required for photosynthesis. The explanation has to make "checkpoint protein helps prevent damaged cells from entering mitosis" fit this stem clue: "Cells are exposed to DNA-damaging radiation. Which conclusion is best supported by the data".

Cell Communication · Concept Explanation

A hormone binds to a receptor on the surface of a target cell. What is the most direct role of the receptor?

  1. ATo replicate the hormone's DNA sequence
  2. BTo recognize the signal and initiate a cellular responsecorrect
  3. CTo digest the plasma membrane completely
  4. DTo prevent all intracellular signaling molecules from forming
Why B is correct

Receptors bind specific signaling molecules and trigger intracellular responses through signal transduction pathways.

The stem asks for a numerical or quantitative judgment: "A hormone binds to a receptor on the surface of a target cell. What is the most direct role of the receptor". The safe route is to identify the counted event, use the full denominator, and then interpret the number biologically. Here the worked reasoning is Receptors bind specific signaling molecules and trigger intracellular responses through signal transduction pathways, so choices based on To replicate the hormone's DNA sequence or To digest the plasma membrane completely lose the required setup.

Common mistakes. Do not stop at a nearby term such as To replicate the hormone's DNA sequence or To digest the plasma membrane completely. The explanation has to make "To recognize the signal and initiate a cellular response" fit this stem clue: "A hormone binds to a receptor on the surface of a target cell. What is the most direct...".

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FAQ

Cell Communication and Cell Cycle questions

What is signal transduction on the AP exam?

Reception, transduction and response — and the exam usually asks what a disrupted step does to the downstream response.

How are checkpoints tested?

Through consequences: what happens to a cell that passes a checkpoint it should have failed.
Last reviewed 2026-08-28. Unit and topic names follow the College Board course framework. Question counts describe the PrepScore practice bank, not the exam.
Topic by topic

Worked questions by topic

3 of this unit’s topics have enough practice questions for a page of their own.

Practise cell communication and cell cycle until the reasoning is automatic.

Real AP questions with a full explanation on every answer, and a mistake bank that only clears when you get it right.